What is the difference between a bio, identical or a synthetic hormone? The reality is, they’re both synthetic meaning they both have to be made, and they’re made from the oils of wild yam and soy However, many people when they talk about synthetic hormones, mean hormones that are made in a lab that don’t actually look similar to your bodies natural state hormones, whereas bio identical has a structure that is almost or is similar to the way that your natural hormone looks . Identical hormone is