Strelka2 introduces a novel mixture-model based estimation of indel error parameters from each sample, an efficient tiered haplotype modeling strategy and a normal sample contamination model to improve …

The Illumina tumor/normal data analysis workflow, consisting of Isaac alignment followed by Strelka small somatic variant calling, demonstrates excellent performance for the detection of somatic …

Here we describe Strelka2, a variant-calling method that builds on the Strelka somatic variant caller7 to improve on these aspects of variant calling for both germline and somatic analysis.

Strelka (single) https://github.com/Illumina/strelka Strelka2 is a fast and accurate small variant caller optimized for analysis of germline variation in small cohorts and somatic variation in tumor/normal …

Sep 25, 2017 · The GRCh38Decoy reference file is available at https://s3.amazonaws.com/strelka- public/GRCh38Decoy/GRCh38Decoy.fa. Below is the procedure to create in silico mixture data using …

We compared Lancet to some of the most widely used somatic variant callers, including MuTect11, MuTect2, LoFreq12, Strelka13, and Strelka214.

In the paper, we focus on detection of short variants, i.e., single nucleotide polymorphisms (SNPs) or short insertions and deletions (indels). To the best of our knowledge, that problem was raised...