Amine oxidase, copper containing 3 (AOC3), also known as vascular adhesion protein (VAP-1) and HPAO is an enzyme that in humans is encoded by the AOC3 gene on chromosome 17.

Nov 13, 2025 · AOC3 (Amine Oxidase Copper Containing 3) is a Protein Coding gene. Diseases associated with AOC3 include Cerebral Amyloid Angiopathy and Diabetic Angiopathy. Among its …

Apr 21, 2021 · AOC3 is a membrane-bound adhesion protein that facilitates the binding of leukocytes to the retinal endothelium. Adherent leukocytes reduce blood flow and in turn rupture blood vessels, …

Mar 9, 2024 · Overall, this study sheds light on the complex interplay of various cell death forms and reveals an autophagy-related gene AOC3 as a critical prognostic marker in CRC.

Selective cytoplasmic expression in smooth muscle, adipocytes, adrenal gland and alveolar cells. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.

Feb 3, 2025 · This paper provides a detailed review of AOC3's structure, function, disease associations, and therapeutic potential. Additionally, we discuss emerging research on AOC3-targeting therapies …

This study showed that the oxidase activity of AOC3 contributes to the development of lung fibrosis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic …

Sep 15, 2008 · HGNC Approved Gene Symbol: AOC3. Members of the semicarbazide-sensitive amine oxidase (SSAO) family, such as AOC3 (EC 1.4.3.6), are expressed on the cell surface and catalyze …

Nov 6, 2023 · AOC3 inhibition, using anti-AOC3 antibodies, has been shown to reduce inflammatory cell recruitment to the liver in murine hepatic injury models and in vitro cultured active hepatic stellate...

Sep 13, 2022 · Amine oxidase copper containing 3 (AOC3) is an enzyme that belongs to the semicarbazide-sensitive amine oxidase (SSAO) family also known as vascular adhesion protein-1 …