Mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Curiously, variants in another gene, TMEM106B, determine when, and how severely, this ...

In 2009, Robert Baloh and colleagues reported a transgenic mouse model of ALS based on the overexpression of mutant TARDBP (TDP-43) (Wegorzewska et al., 2009). These mice developed several features of ...

Scientists are trying to parse the cellular interactions that foment ARIA during amyloid immunotherapy. At last month’s AD/PD conference in Copenhagen, Denmark, speakers highlighted the role of both ...

Scientists are getting closer to figuring out how amyloid immunotherapy causes ARIA, and perhaps how to prevent it. At last month’s AD/PD conference in Copenhagen, Denmark, the spotlight was on innate ...

The dbl-PAC-Tg(SNCA A53T) +/+;Snca-/-model, referred to here as double-transgenic mice, are mice lacking endogenous α-synuclein (Snca knockout mice) that were crossed with two homozygous transgenic ...

Interconnected networks of neurons—i.e., circuits—are the basis of brain function, and astrocytes support synapses within them. They also form networks of their own, passing messages and sharing ...