Whether extended lymphadenectomy is associated with improved disease-free and overall survival, as compared with standard lymphadenectomy, among patients with localized muscle-invasive bladder ...

CAR T-cell manufacturing involves T-cell apheresis, CAR transduction, and expansion of transduced autologous or allogeneic T cells. To date, approved CAR T-cell products rely on lentiviral ...

The next U.S. president will inherit multiple epidemics with inequitably distributed effects. Kamala Harris and Donald Trump are likely to take divergent policy approaches to addressing these crises.

In order to ensure timely testing of drugs that have been granted accelerated approval, the FDA can impose civil monetary penalties on dilatory manufacturers — but has never done so. This ...

U.S. states, which are better positioned than the federal government to precisely and comprehensively address the drivers of low-value health care spending, should lead the way in establishing ...

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

A 32-year-old man with well-controlled human immunodeficiency virus infection presented with painful nodules on his forehead and a rash on his trunk. A bone scan showed uptake in the nodules.

For permission requests, please contact NEJM Reprints at [email protected] ...

Outcomes of elections for the presidency and Congress and in the states could have profound effects on the coverage available to tens of millions of Americans. From New York University, New York ...

From the Department of Health Care Policy, Harvard Medical School, and the Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital — both in Boston (J.M.M.); and ...

On the basis of 28 national opinion polls, the authors summarize Democrats’ and Republicans’ views on health policy issues and discuss the implications of the 2024 election outcome for U.S ...