TFC has been formally incorporated into the Unified Huntington’s Disease Rating Scale (UHDRS), which is the standard clinical ...

Apathy in people with Huntington’s disease (HD) isn’t just a lack of interest or motivation, it is a loss of drive, initiative, and emotional responsiveness that affects not only what the person with ...

If CRISPR stays active too long, it could cut unintended parts of the genome. To reduce this risk, the researchers designed a self-inactivating CRISPR system. This means that CRISPR edits the gene and ...

HDBuzz has always been free to read, and we intend to keep it that way. But free to read doesn’t mean free to run. As an ...

Long repetitive sequences of C-A-G letters in the DNA code are associated with at least 12 genetic diseases, including Huntington’s disease (HD). A group of scientists in Massachusetts, USA, have ...

In plain language. Written by scientists. For the global HD community.

Transplanting healthy human glial cells into HD mouse brains improved movement, memory, and survival. Even more strikingly, the glia coaxed diseased neurons to behave more like healthy ones, offering ...

This week, we heard an update from Roche about their huntingtin-lowering therapy, tominersen, currently being tested in the GENERATION HD2 trial. An independent data monitoring committee (iDMC) that ...

Last month, we relayed positive news from uniQure’s trial testing AMT-130, a gene therapy delivered via brain surgery to lower huntingtin (HTT). Data released by uniQure in June suggested AMT-130 was ...

For those who were following the live tweets from HDBuzz about the CHDI HD Therapeutics Conference or tuned in to the HDSA Convention, we may have caught your attention with the new HD staging system.

Huntingtin lowering has gained lots of attention in HD research, and for good reason. It was the first potential treatment designed to directly target the cause of HD – the huntingtin protein. But ...