San Francisco 49ers running back Christian McCaffrey won't return in Week 6, but will likely make his long-awaited comeback ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...

Arizona shuts down San Francisco in second half to stage late rally after trailing by as much as 13 points on the road.

The San Francisco 49ers (2-2) meet a fellow NFC West foe when they host the Arizona Cardinals (1-3) on Sunday, October 6, ...

The record-breaking heat at Levi's Stadium on Sunday sent San Francisco 49ers fans to the concourses to watch the game on ...

San Francisco 49ers linebacker Dre Greenlaw shoved a Cardinals player in a sideline skirmish during Sunday's game, likely ...

The 49ers (2-3) blew a 10-point, fourth-quarter lead and fell 24-23 to the visiting Arizona Cardinals in record heat at ...

Niners defensive tackle Jordan Elliott blocked a field goal attempt and Lenoir ran it back for a touchdown to extend the ...

Even the kicker suffered an injury, and it probably cost them a game. The 49ers had a 10-point lead in the fourth quarter on ...

This marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division ...

Kyle Juszczyk took a shot at Niner beat reporter Grant Cohn, implying that a married man is gay. Whether Juszczyk was saying ...

After two plays, the San Francisco 49ers leading receiver exited Sunday’s Week 5 game with an apparent injury. After opening ...