Using mice, lab-grown cells and clues from a related disorder, researchers have greatly increased understanding of the causes of systemic sclerosis, showing that a critical culprit is a defect in the ...

EXTENSIVE clinical data have been accumulated during recent years that support the view that scleroderma is a systemic disease. In addition to cutaneous involvement, which remains the cardinal ...

Systemic sclerosis (SSc) is a multisystem disease of unknown aetiology characterised by microangiopathy, dysregulated immune function and tissue remodelling. Evidence of each of these three heavily ...

CARLSBAD, California — In 2003, researchers asked 303 patients with systemic sclerosis (scleroderma) what bothered them most about their disease from an aesthetic standpoint: Orofacial features, such ...

Systemic sclerosis (SSc), also known as scleroderma, is a complex connective tissue disease that is associated with a high mortality and is challenging to treat because of its clinical heterogeneity ...

Scleroderma is a range of disorders in which the skin and connective tissues tighten and harden. It is a long-term, progressive disease. This means it gradually gets worse. Share on Pinterest ...

Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell ...

Researchers have uncovered cancer-like genetic mutations in the affected cells of people with scleroderma, pointing the way to potential new ways to treat the debilitating and sometimes fatal skin and ...

The scleroderma skin pinch test checks the thickness and elasticity of your skin. It can help doctors diagnose and monitor scleroderma, an autoimmune condition that causes inflammation and thickening ...

Sclerodactyly is a tightening and thickening of the skin of the fingers as a result of systemic scleroderma. It can cause the fingers to curl inward and the hands to form a clawed shape. Share on ...

Systemic sclerosis (SSc), or scleroderma, is a chronic, multisystem autoimmune rheumatic disease characterized by exaggerated fibrosis, vasculopathy, and derangements of the immune system. When ...