The spatial organization of the genome within the nucleus — also known as genome architecture or 3D genome — is important to the regulation of gene expression. Disruption of the 3D genome, for example ...

Researchers have found that the DNA spools inside human cells are far less tightly wound than textbooks have long suggested.

The extent of genetic variation and its influence on gene expression is still being characterized, as the regulation of specific genes is highly dependent on tissue and cellular context 1,2.

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

A new genomic method has enabled multiple people with rare conditions to receive diagnoses that were previously unattainable by identifying complex structural genetic changes that are often missed by ...