The equipoise randomization strategy allowed patients to indicate a preference to which of the level 2 options they would accept or refuse. Only 1% of the cohort would accept all 7 treatment options.

I am no stranger to the importance of randomization when conducting a study. I minored in psychology as an undergraduate, so I took part in the experimentation process--both by being experimented on ...

The quality and safety of a biopharmaceutical is determined by how well its manufacture is controlled. The challenge is that the modeling methods used to develop control strategies sometimes struggle ...

The genetic and clinical heterogeneity of breast cancer makes the identification of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen ...