Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as AlphaFold3, to predict. Researchers at the Institute for ...

Scientists at St. Jude Children's Research Hospital have created a database that provides updated predicted structures on a regular basis, ensuring scientists can work with the most current ...

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing ...

A single human gene can produce multiple protein isoforms through alternative splicing, greatly expanding the functional diversity of the proteome. Yet despite decades of research, scientists still ...

For decades, scientists have understood proteins primarily through two defining features: their amino acid sequence and their ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

AI systems have recently had a lot of success in one key aspect of biology: the relationship between a protein’s structure and its function. These efforts have included the ability to predict the ...

Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level ...

A protein's function is determined by its structure, and structure—the way a protein folds—is determined by its sequence of amino acids, the building blocks of proteins.