Advanced engineered cell therapies require gene editing tools that are both precise and efficient. In recent years, CRISPR-Cas9 has emerged as the gold standard for editing genes with greater ...

Cell-autonomous circadian clocks coordinate daily physiological timing, allowing them to synchronize with the environment. However, the initial signaling events shared by diverse synchronizing cues ...

Abnormalities in TDP-43 (Transactive response DNA-binding protein 43 kDa) localization and function span multiple neurodegenerative diseases and are implicated in driving neuronal degeneration and ...

Each cell contains well-defined compartments, each of which has a specific function. The nuclear envelope, for example, is a highly regulated membrane barrier that separates the nucleus from the ...

CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing nuclear accumulation ...

Studies headed by researchers at the Centre for Genomic Regulation (CRG) have found that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected ...