In the AFC, the New England Patriots are favored even after the top-seeded Denver Broncos defeated the Buffalo Bills on Saturday, losing quarterback Bo Nix to an ankle injury in the final plays of the game. The Patriots face the Houston Texans with the winner playing in Denver next week.

After that win, a bettor at BetMGM in Illinois wagered $50,000 on the Bears at 66-1 odds to win Super Bowl LX. The bet would've won $3.3 million, and ws the largest reported Super Bowl futures bet by total liability at any legal sportsbook in the United States. BetMGM moved Chicago's Super Bowl odds as a result of the wager.

There were more head-coaching openings this year than any other offseason, but the Giants' addition of John Harbaugh will carry more influence than any other move, from a betting standpoint.

Among the favorites to win the NFL's Most Valuable Player award this season is Christian McCaffrey, who currently has the fifth-best odds in the league, at +30000.

The NFL coach carousel continues to turn as teams reshuffle their decks. The Bills joined the Steelers and Ravens, two of the three teams with coaches who had a longer tenure with one coach this season,

There have been 256 NFL games played this regular season, and after Week 18, we get to 272 and move on to the postseason. With the interconnectivity of the final slate of games, the league will play all 16 this week in a two-day window on Saturday and ...

Bijan Robinson is +3500 to win the NFL's Offensive Player of the Year award in 2025, the third-best odds in the league. He leads the team with 1,445 yards (90.3 ypg) on 272 rushes and has gotten into the end zone seven times. In addition, he has 810 receiving yards (50.6 ypg) on 76 catches while scoring four receiving touchdowns.