Antipsychotic medications exert their therapeutic effects primarily through modulation of neurotransmitter systems in the brain, most notably by antagonising dopamine D2 receptors within mesolimbic ...

The US Food and Drug Administration (FDA) is due to issue a decision by September 26 on the approval of KarXT, a potential first-in-class antipsychotic. If approved, it would be the first drug with a ...

SAN FRANCISCO — The US Food and Drug Administration (FDA) has granted breakthrough therapy designation to a potentially first-in-class psychotropic agent with a completely different mechanism of ...

Paliperidone 3 mg, 6 mg, 9 mg; extended-release tabs. Paliperidone is the major active metabolite of risperidone. Although the mechanism of action of this atypical antipsychotic is unknown, the ...

In fall 2024, xanomeline trospium chloride (XT) was approved by the U.S. Food and Drug Administration for the treatment of adults with schizophrenia. In an earlier post, we reviewed evidence that this ...

The mechanism of action of Wegovy (how it works) may vary depending on the indication(s) for which it is prescribed. Here is what experts know about Wegovy’s mechanism of action for its approved uses.

This post was written by Eugene Rubin, MD, Ph.D., and Charles Zorumski, MD. Schizophrenia is a severe, chronic disorder characterized by "positive" symptoms such as hallucinations, delusions (fixed, ...