Integrins are heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix and engage bidirectional signalling across the plasma membrane. Activation is controlled by ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused immense suffering and economic hardship to millions of people worldwide. To date, the mechanism of infection by SARS-CoV-2 ...

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...

The movement of leukocytes from the circulatory system to the site of inflammation and subsequent attachment forms an integral part of the innate immune system. The three steps of leukocyte rolling, ...

Integrin αIIbβ3 is the principal adhesion receptor on platelets and serves as a fulcrum for bidirectional signal transduction that underpins haemostasis and thrombosis. In resting platelets, αIIbβ3 ...