In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and ...

Although variants in TNFAIP3, which encodes the NF-κB regulatory protein A20, have been linked with susceptibility to systemic sclerosis (SSc), little has been revealed about the function and ...

Human skin is constantly rebuilding itself. Every few weeks, the outermost layers shed and are replaced by new cells pushed ...

Hypertrophic scars (HS) are abnormal outcomes of wound healing, marked by excessive extracellular matrix (ECM) deposition and ...

SCI often causes long-term motor and sensory deficits because the damaged tissue does not simply heal like many peripheral tissues.

Fibroblast growth factor 2 (FGF2) is a crucial factor in odontoblast differentiation and dentin matrix deposition, which facilitates pulpodentin repair and regeneration. Nevertheless, the specific ...

In a significant breakthrough in inflammatory arthritis research, a study published today (Feb. 23) in Nature Immunology has revealed that inflammation-associated fibroblasts—a type of cell in ...

Infigratinib demonstrated antitumour activity in FGFR2 amplified gastric cancer with a 23.8% response rate and manageable ...

The allowed application, U.S. Patent Application No. 18/184,726, contains 19 allowed claims directed to methods of treating and accelerating the healing of wounds by topically administering a ...

A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer ...

Helmholtz Munich researchers revealed a conserved differentiation process with clinical implications for injury repair, identifying a multipotent fibroblast progenitor in the fascia— the deepest ...

Diabetic foot ulcers can remain open for weeks or months, leaving patients at risk of infection, hospitalization, and ...