Open Heart

Blinding and quality of life endpoints in randomised trials of stable angina: a meta-epidemiological study

Background Quality of life (QoL) measures are commonly used in randomised trials assessing therapies for stable angina. As ...

Clinical Trials Aren’t the Only Way to Know if Flu Shots Work

With a bit of creativity, evidence can be drawn from data we already have in the form of natural experiments, write ...
ascopubs.org

Cognitive effects of darolutamide vs enzalutamide: Results of ARACOG (AFT-47), a randomized clinical trial from the Alliance for Clinical Trials in Oncology.

A phase 2 trial of androgen deprivation therapy interruption in patients responding exceptionally to androgen receptor pathway inhibitor in metastatic hormone-sensitive prostate cancer (A-DREAM / ...
ascopubs.org

Using Indirect Comparisons of Prospective, Randomized Trials to Make Therapeutic Decisions in Melanoma: Cross-Trial Comparisons as Surrogates for Proper Head-To-Head Studies?

Can We Offset Local Recurrence in Locally Advanced Non–Small Cell Lung Cancer? The Merry-Go-Round of Radiation Dose Escalation and Stubborn Outcomes First-Line Nivolumab Plus Relatlimab Versus ...