Chemical structure for thiamine pyrophosphate and protein structure of transketolase. Thiamine pyrophosphate cofactor in yellow and xylulose 5-phosphate substrate in black. Credit: Thomas ...

Every time a eukaryotic cell divides, it faces a monumental challenge: It must carefully duplicate and divide its genetic ...

Researchers participating in the Enzyme Function Initiative (EFI) have used a computationally rich metabolite-docking strategy to sift through a protein’s potential metabolic partners and predict its ...

Annotations of enzyme function provide critical starting points for generating and testing biological hypotheses, but the quality of functional annotations is hindered by uncertain assignments for ...

Enzymes are substances in the body that cause and speed up crucial chemical reactions. Enzymes’ function is to help trigger ...

Cytochrome P450 enzymes constitute a superfamily of haem-containing proteins that catalyse the oxidation of a wide range of exogenous and endogenous compounds. Their function is fundamental to the ...

Patients with lupus are at increased risk of heart disease. Exposing endothelial cells -- known to protect against heart disease, in part by producing nitric oxide -- to the serum of patients with ...

Aging, neurological diseases and our bodies' stress response are all linked to the tiny power plants inside each cell known ...

Switching off a single enzyme in immune cells protected mice from obesity, type 2 diabetes, and fatty liver disease in a new ...

Researchers at Baylor College of Medicine and collaborating institutions report in the journal Nature Communications how a mutation in the enzyme SKD3 can cause a form of a genetic disease known as ...

Imlifidase, an IgG-destroying enzyme, could receive FDA approval in the second half of 2026 and hit peak sales of $306 ...

Another protein central to this process is NuMA, which is essential for spindle pole organisation. Normally, NuMA gathers at ...