Researchers from the University of Copenhagen have mapped the structure of an important channel in human muscle cells. The new insights about the chloride channel can contribute to greater ...

Using pore radius calculations, Deng et al. showed how the central ion conduction pore contained multiple constrictions to prevent ion passage. The structure represented nonconductive conformation due ...

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present ...

Laboratory cell experiments and computer simulations have revealed molecular mechanisms regulating a protein channel responsible for transporting chloride and other charged molecules across cell ...

Mutations in another kind of chloride channel, called the CFTR, are responsible for cystic fibrosis, the most common genetic disease in Caucasian populations. There are many varieties of ion channels.

Rodent ClC-K1 and ClC-K2, and their respective human orthologs ClCKA and ClCKB, are chloride channels specific to the kidney (and inner ear); Barttin is their functionally important subunit. ClC-K1 is ...

Scientists have generated structural images of a newly-described class of ion channels that help maintain the balance of pH inside brain cells. These molecular gates, called proton-activated chloride ...

In the human body the salt content of cells and their surrounding is regulated by sophisticated transport systems. Special channels in the cell membrane selectively permit salt ions to flow in and out ...

Hyperaldosteronism is a disease primarily affecting the adrenal glands that leads to high blood pressure due to overproduction of the hormone aldosterone and that may also damage the kidneys. It has ...

Laboratory cell experiments and computer simulations have revealed molecular mechanisms regulating a protein channel responsible for transporting chloride and other charged molecules across cell ...