Self-reactive and polyreactive B cells generated during B cell development are silenced by either apoptosis, clonal deletion, receptor editing or anergy to avoid autoimmunity. The specific ...

Scientists discovered which tumor cells resist treatment and why. By characterizing B-cells' developmental stages, they designed and tested a drug combination to effectively treat resistant B-cell ...

Terminal differentiation of B cells to Memory fate is a multi-factorial process. There is no single master regulator for fate determination in dividing B cells. Interaction with T cells play important ...