SINCE the introduction of nitrogen mustard, methyl-bis-β-(chloroethyl)-amine, or HN 2 (Fig. 1), as a therapeutic agent in human cancer a number of analogues and related alkylating agents have been ...

(HealthDay)—For patients treated for Hodgkin's lymphoma (HL), cumulative doses of alkylating agent (AA) is associated with the risk of therapy-related acute myeloid leukemia/myelodysplastic syndrome ...

Large Cleaved and Immunoblastic Lymphoma May Represent Two Distinct Clinicopathologic Entities Within the Group of Diffuse Large B-Cell Lymphomas t(4;14)-positive patients had a predominance of the ...

Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic risk ...

Researchers at Princeton have developed a dual catalyst system that directly installs alkyl groups—fragments containing singly bonded carbon and hydrogen atoms that have extremely useful properties ...

Our database for multiple myeloma included 80 patients who had stem cell mobilization between 1998 and 2001 in anticipation of autologous transplant. The 50 patients included in this study had not ...

None of the above studies reported increased risk of breast cancer after leukemia, or evaluated the influence of chemotherapy on breast cancer risk in survivors unexposed to chest radiotherapy.

Therapy-related acute myeloid leukaemia (t-AML) is a late complication of chemotherapy and/or radiotherapy given for a primary disorder, usually a cancer, and represents upto 10% of all AML cases ...

Please provide your email address to receive an email when new articles are posted on . Women who had childhood cancer may have an increased risk for premature ovarian insufficiency after treatment ...

Higher cumulative exposure to alkylating agents is independently associated with impaired spermatogenesis in adult survivors of childhood cancer. Higher cumulative alkylating agent exposure is ...

Researchers have developed a dual catalyst system that directly installs alkyl groups -- fragments containing singly bonded carbon and hydrogen atoms that have extremely useful properties for drug ...

Alkylating Agent Linked to Therapy-Related Leukemia For patients treated for Hodgkin's lymphoma (HL), cumulative doses of alkylating agent (AA) is associated with the risk of therapy-related acute ...